Neurological Disease

ZD7288 (Standard) is the analytical standard of ZD7288 (HY-101346). This product is intended for research and analytical applications. ZD7288 (ICI D7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker.

Acetylcholine (iodide) (Standard) is the analytical standard of Acetylcholine (iodide). This product is intended for research and analytical applications. Acetylcholine iodide (ACh iodide) is a common neurotransmitter found in the central and peripheral nerve system.

Cannabidivarin diacetateis structurally similar to known phytocannabinoids.

Tiospirone is a 5-HT₂ receptor antagonist with affinity for D₂, 5-HT_1a, and 5-HT₇, and sigma receptors. Tiospirone decreases consumption of ethanol while increasing food intake of rats. Tiospirone can also reduce the reinforcing properties of Cocaine exhibited in the conditioned place preference paradigm.

GSK-3 inhibitor 7 (compound 22) is a glycogen synthase kinase-3 (GSK-3) inhibitor. GSK-3 inhibitor 7 can be used in nervous system research.

Gliquidone sodium (AR-DF 26 sodium) can bind to the pancreatic β-cells and increases insulin release to regulate blood glucose levels. Gliquidone sodium significantly decreases LPS (HY-D1056)-induced proinflammatory responses and inhibits ERK/STAT3/NF-κB phosphorylation in BV2 microglial cells. Gliquidone sodium can suppress microgliosis, microglial hypertrophy mediated by LPS, and proinflammatory cytokine COX-2 and IL-6 levels in murine model. Gliquidone sodium also exhibits good anticancer activity in lung carcinoma cells. Gliquidone sodium has antioxidant property. Gliquidone sodium can be studied in research for type 2 diabetes and cancers.

SIRT6 modulator-1 is a SIRT6 modulator.

Xanomeline (Standard) is the analytical standard of Xanomeline. This product is intended for research and analytical applications. Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia.

Pridinol mesylate (Standard) is the analytical standard of Pridinol mesylate (HY-B1343). This product is intended for research and analytical applications. Pridinol mesylate is an orally active, blood-brain permeable, muscarinic acetylcholine receptor (mAChR)-directed muscle relaxant. Pridinol mesylate reduces the conduction of impulses to spinal motor neurons and exerts muscle relaxant activity. Pridinol mesylate inhibits skeletal muscle contractures in diseases of both central and peripheral origin and can be used in research in the field of musculoskeletal diseases.

Human PAX2 mRNA encodes the human paired box 2 (PAX2) protein, a member of the paired box (PAX) family. PAX2 may have a role in kidney cell differentiation and the development of the urogenital tract, the eyes, and the CNS.

CID1172084 (compound 3) is a selective GPR55 agonist (EC₅₀=0.16 μM). CID1172084 is more than 100-fold selective for GPR55 over GPR35, CB1, and CB2. CID1172084 can be used to further explore the biological functions and signaling pathways of the GPR55 receptor.

PTI-1 is a synthetic cannabinoid (CB) that contains the 1-pentyl-indole structure.

25T4-NBOMe hydrochloride is a derivative of 2C-T-4, characterized by the addition of a benzyl-methoxy (BOMe) group to the amine.

Zotepine (Standard) is the analytical standard of Zotepine. This product is intended for research and analytical applications. Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT_2A, 5-HT_2C, Histamine H₁, α₁-adrenergic and Dopamine D₂ receptors, with K_ds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively. Zotepine exhibits antidepressive and anxiolytic effects in vivo.

AM-2099 (Standard) is the analytical standard of AM-2099 (HY-100727). This product is intended for research and analytical applications. AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 with an IC50 of 0.16 μM for human Nav1.7.

Methylspinazarin is a potent inhibitor of catechol O-methyltransferase (COMT, IC₅₀ = 0.8 μg/ml) that can be isolated from Streptomyces. Methylspinazarin is selective for COMT over tyrosine hydroxylase.